The church we see today only partially recalls the original project, because Brunelleschi died in 1446 and work was then continued by three different architects.

In 1480 the dome was completed, with a characteristic covering of terracotta 'scales'.

In 1503 and 1517 the slender campanile, designed by Baccio d'Agnolo, was erected, while in the 16th century two fine cloisters were built on the left side of the church.

The interior represents a magnificent example of Renaissance architecture, divided into three aisles by 34 elegant columns of pietra serena with corinthian capitals.

Among the works of great interest housed in Santo Spirito, those not to be missed are: the 17th century altarpiece in stucco and marble, the 15th century panel showing the 'Madonna del Soccorso', the splendid 'Madonna and Child with the young St. John and Saints' by Filippino Lippi, the 15th century painting portraying S.Monica establishing the Augustinian Order, and the Cappella Corbinelli with beautiful decoration and an altarpiece by Sansovino.